Hi! RouterOS 7.8 here and the exact same behavior. Smartphone on 4G connected through Wireguard to RB4011, can't even reach the router itself. If I disable and then enable the peer it will work instantly.

Did you find a fix?

Thanks.

- Cristiano

Just ran into that problem as well. This happened because I changed the my home directory on Windows. Apparently the Winbox app accesses the following registry entry to check for the location of the session folder: Computer\HKEY_CURRENT_USER\SOFTWARE\Microsoft\Windows\CurrentVersion\Explorer\Shell ...