Hello, this same thing was driving me crazy as well, so I gathered all Microsoft's BGP prefixes and created access list in order to block them completely - during hours I don't want them to spend my traffic. Windows update does not work, web access to Bing does not work, no Microsoft telemetry works, Skype doesn't work. The only thing that works are some MS localized websites since they are not always hosted in their own AS's.
The list is compiled a month ago from fresh LG on the internet, and here is MikroTik friendly format that allows you to do whatever you like with scheduling Windows machines' access to Microsoft services (selectively allowing them to update in certain time-frame, or shaping/throttlng bandwidth):
/ip firewall address-list add list=microsoft address=65.53.0.0/16
/ip firewall address-list add list=microsoft address=65.54.0.0/24
/ip firewall address-list add list=microsoft address=65.54.1.0/24
/ip firewall address-list add list=microsoft address=65.54.2.0/24
/ip firewall address-list add list=microsoft address=65.55.28.0/23
/ip firewall address-list add list=microsoft address=65.55.28.0/22
/ip firewall address-list add list=microsoft address=65.55.188.0/24
/ip firewall address-list add list=microsoft address=70.42.230.0/23
/ip firewall address-list add list=microsoft address=104.44.112.0/24
/ip firewall address-list add list=microsoft address=131.107.0.0/20
/ip firewall address-list add list=microsoft address=131.107.217.0/24
/ip firewall address-list add list=microsoft address=131.107.0.0/16
/ip firewall address-list add list=microsoft address=157.54.0.0/16
/ip firewall address-list add list=microsoft address=157.57.0.0/16
/ip firewall address-list add list=microsoft address=157.58.192.0/19
/ip firewall address-list add list=microsoft address=157.58.248.0/23
/ip firewall address-list add list=microsoft address=157.58.0.0/16
/ip firewall address-list add list=microsoft address=157.59.0.0/16
/ip firewall address-list add list=microsoft address=157.60.0.0/16
/ip firewall address-list add list=microsoft address=167.220.8.0/24
/ip firewall address-list add list=microsoft address=167.220.9.0/24
/ip firewall address-list add list=microsoft address=167.220.10.0/24
/ip firewall address-list add list=microsoft address=167.220.24.0/22
/ip firewall address-list add list=microsoft address=167.220.16.0/20
/ip firewall address-list add list=microsoft address=167.220.40.0/21
/ip firewall address-list add list=microsoft address=167.220.48.0/21
/ip firewall address-list add list=microsoft address=167.220.64.0/19
/ip firewall address-list add list=microsoft address=167.220.0.0/17
/ip firewall address-list add list=microsoft address=167.220.148.0/22
/ip firewall address-list add list=microsoft address=167.220.152.0/24
/ip firewall address-list add list=microsoft address=167.220.236.0/22
/ip firewall address-list add list=microsoft address=167.220.248.0/21
/ip firewall address-list add list=microsoft address=198.105.232.0/22
/ip firewall address-list add list=microsoft address=198.180.95.0/24
/ip firewall address-list add list=microsoft address=199.2.137.0/24
/ip firewall address-list add list=microsoft address=199.242.48.0/22
/ip firewall address-list add list=microsoft address=204.182.144.0/24
/ip firewall address-list add list=microsoft address=204.255.244.0/23
/ip firewall address-list add list=microsoft address=167.220.192.0/22
/ip firewall address-list add list=microsoft address=167.220.196.0/22
/ip firewall address-list add list=microsoft address=167.220.200.0/24
/ip firewall address-list add list=microsoft address=167.220.201.0/24
/ip firewall address-list add list=microsoft address=194.69.96.0/22
/ip firewall address-list add list=microsoft address=194.69.100.0/22
/ip firewall address-list add list=microsoft address=194.69.126.0/23
/ip firewall address-list add list=microsoft address=13.107.3.0/24
/ip firewall address-list add list=microsoft address=13.107.4.0/24
/ip firewall address-list add list=microsoft address=13.107.5.0/24
/ip firewall address-list add list=microsoft address=13.107.6.0/24
/ip firewall address-list add list=microsoft address=13.107.7.0/24
/ip firewall address-list add list=microsoft address=13.107.9.0/24
/ip firewall address-list add list=microsoft address=13.107.12.0/24
/ip firewall address-list add list=microsoft address=13.107.13.0/24
/ip firewall address-list add list=microsoft address=13.107.15.0/24
/ip firewall address-list add list=microsoft address=13.107.16.0/24
/ip firewall address-list add list=microsoft address=13.107.18.0/24
/ip firewall address-list add list=microsoft address=13.107.21.0/24
/ip firewall address-list add list=microsoft address=13.107.22.0/24
/ip firewall address-list add list=microsoft address=13.107.24.0/24
/ip firewall address-list add list=microsoft address=13.107.44.0/24
/ip firewall address-list add list=microsoft address=13.107.58.0/24
/ip firewall address-list add list=microsoft address=13.107.160.0/24
/ip firewall address-list add list=microsoft address=40.90.4.0/24
/ip firewall address-list add list=microsoft address=64.4.48.0/24
/ip firewall address-list add list=microsoft address=65.54.192.0/24
/ip firewall address-list add list=microsoft address=65.54.193.0/24
/ip firewall address-list add list=microsoft address=65.54.195.0/24
/ip firewall address-list add list=microsoft address=65.54.196.0/24
/ip firewall address-list add list=microsoft address=65.54.197.0/24
/ip firewall address-list add list=microsoft address=65.54.198.0/24
/ip firewall address-list add list=microsoft address=65.54.199.0/24
/ip firewall address-list add list=microsoft address=65.54.200.0/24
/ip firewall address-list add list=microsoft address=65.54.201.0/24
/ip firewall address-list add list=microsoft address=65.54.202.0/24
/ip firewall address-list add list=microsoft address=65.54.203.0/24
/ip firewall address-list add list=microsoft address=65.54.207.0/24
/ip firewall address-list add list=microsoft address=65.54.208.0/24
/ip firewall address-list add list=microsoft address=65.54.210.0/24
/ip firewall address-list add list=microsoft address=65.54.211.0/24
/ip firewall address-list add list=microsoft address=65.54.213.0/24
/ip firewall address-list add list=microsoft address=65.54.215.0/24
/ip firewall address-list add list=microsoft address=65.54.216.0/24
/ip firewall address-list add list=microsoft address=65.54.219.0/24
/ip firewall address-list add list=microsoft address=65.54.222.0/24
/ip firewall address-list add list=microsoft address=65.54.223.0/24
/ip firewall address-list add list=microsoft address=94.245.84.0/24
/ip firewall address-list add list=microsoft address=104.44.66.0/24
/ip firewall address-list add list=microsoft address=104.44.67.0/24
/ip firewall address-list add list=microsoft address=104.44.68.0/24
/ip firewall address-list add list=microsoft address=104.44.69.0/24
/ip firewall address-list add list=microsoft address=104.44.75.0/24
/ip firewall address-list add list=microsoft address=131.253.21.0/24
/ip firewall address-list add list=microsoft address=204.14.180.0/24
/ip firewall address-list add list=microsoft address=204.79.197.0/24
/ip firewall address-list add list=microsoft address=131.253.72.0/22
/ip firewall address-list add list=microsoft address=131.253.80.0/20
/ip firewall address-list add list=microsoft address=131.253.112.0/21
/ip firewall address-list add list=microsoft address=131.253.120.0/22
/ip firewall address-list add list=microsoft address=167.220.232.0/22
/ip firewall address-list add list=microsoft address=103.25.156.0/24
/ip firewall address-list add list=microsoft address=103.36.96.0/22
/ip firewall address-list add list=microsoft address=103.255.140.0/23
/ip firewall address-list add list=microsoft address=103.255.140.0/22
/ip firewall address-list add list=microsoft address=111.221.28.0/24
/ip firewall address-list add list=microsoft address=202.89.232.0/21
/ip firewall address-list add list=microsoft address=167.220.28.0/23
/ip firewall address-list add list=microsoft address=167.220.237.0/24
/ip firewall address-list add list=microsoft address=13.64.0.0/11
/ip firewall address-list add list=microsoft address=13.107.20.0/24
/ip firewall address-list add list=microsoft address=13.104.0.0/14
/ip firewall address-list add list=microsoft address=23.96.0.0/14
/ip firewall address-list add list=microsoft address=23.100.0.0/15
/ip firewall address-list add list=microsoft address=23.102.0.0/16
/ip firewall address-list add list=microsoft address=23.103.64.0/18
/ip firewall address-list add list=microsoft address=23.103.128.0/17
/ip firewall address-list add list=microsoft address=40.64.0.0/10
/ip firewall address-list add list=microsoft address=51.10.0.0/15
/ip firewall address-list add list=microsoft address=51.12.0.0/15
/ip firewall address-list add list=microsoft address=51.18.0.0/16
/ip firewall address-list add list=microsoft address=51.51.0.0/16
/ip firewall address-list add list=microsoft address=51.53.0.0/16
/ip firewall address-list add list=microsoft address=51.103.0.0/16
/ip firewall address-list add list=microsoft address=51.104.0.0/15
/ip firewall address-list add list=microsoft address=51.107.0.0/16
/ip firewall address-list add list=microsoft address=51.116.0.0/16
/ip firewall address-list add list=microsoft address=51.120.0.0/16
/ip firewall address-list add list=microsoft address=51.124.0.0/16
/ip firewall address-list add list=microsoft address=51.132.0.0/16
/ip firewall address-list add list=microsoft address=51.136.0.0/15
/ip firewall address-list add list=microsoft address=51.138.0.0/16
/ip firewall address-list add list=microsoft address=51.140.0.0/14
/ip firewall address-list add list=microsoft address=51.144.0.0/15
/ip firewall address-list add list=microsoft address=52.96.0.0/12
/ip firewall address-list add list=microsoft address=52.112.0.0/14
/ip firewall address-list add list=microsoft address=52.120.0.0/14
/ip firewall address-list add list=microsoft address=52.125.0.0/16
/ip firewall address-list add list=microsoft address=52.126.0.0/15
/ip firewall address-list add list=microsoft address=52.130.0.0/15
/ip firewall address-list add list=microsoft address=52.132.0.0/14
/ip firewall address-list add list=microsoft address=52.136.0.0/13
/ip firewall address-list add list=microsoft address=52.145.0.0/16
/ip firewall address-list add list=microsoft address=52.146.0.0/15
/ip firewall address-list add list=microsoft address=52.148.0.0/14
/ip firewall address-list add list=microsoft address=52.152.0.0/13
/ip firewall address-list add list=microsoft address=52.160.0.0/11
/ip firewall address-list add list=microsoft address=52.224.0.0/11
/ip firewall address-list add list=microsoft address=65.55.44.0/24
/ip firewall address-list add list=microsoft address=65.55.117.0/24
/ip firewall address-list add list=microsoft address=65.52.0.0/14
/ip firewall address-list add list=microsoft address=66.119.144.0/20
/ip firewall address-list add list=microsoft address=70.37.0.0/17
/ip firewall address-list add list=microsoft address=70.37.128.0/18
/ip firewall address-list add list=microsoft address=94.245.64.0/18
/ip firewall address-list add list=microsoft address=104.40.0.0/13
/ip firewall address-list add list=microsoft address=104.146.0.0/19
/ip firewall address-list add list=microsoft address=104.146.128.0/17
/ip firewall address-list add list=microsoft address=104.208.0.0/13
/ip firewall address-list add list=microsoft address=111.221.16.0/20
/ip firewall address-list add list=microsoft address=111.221.64.0/18
/ip firewall address-list add list=microsoft address=131.253.1.0/24
/ip firewall address-list add list=microsoft address=131.253.5.0/24
/ip firewall address-list add list=microsoft address=131.253.6.0/24
/ip firewall address-list add list=microsoft address=131.253.8.0/24
/ip firewall address-list add list=microsoft address=131.253.12.0/22
/ip firewall address-list add list=microsoft address=131.253.18.0/24
/ip firewall address-list add list=microsoft address=131.253.24.0/21
/ip firewall address-list add list=microsoft address=131.253.33.0/24
/ip firewall address-list add list=microsoft address=131.253.32.0/20
/ip firewall address-list add list=microsoft address=131.253.61.0/24
/ip firewall address-list add list=microsoft address=131.253.62.0/23
/ip firewall address-list add list=microsoft address=131.253.128.0/17
/ip firewall address-list add list=microsoft address=132.245.0.0/16
/ip firewall address-list add list=microsoft address=134.170.0.0/16
/ip firewall address-list add list=microsoft address=137.116.0.0/15
/ip firewall address-list add list=microsoft address=137.135.0.0/16
/ip firewall address-list add list=microsoft address=137.135.128.0/17
/ip firewall address-list add list=microsoft address=138.91.0.0/16
/ip firewall address-list add list=microsoft address=138.196.0.0/16
/ip firewall address-list add list=microsoft address=146.147.0.0/16
/ip firewall address-list add list=microsoft address=150.171.0.0/16
/ip firewall address-list add list=microsoft address=157.55.0.0/16
/ip firewall address-list add list=microsoft address=157.56.0.0/16
/ip firewall address-list add list=microsoft address=157.60.23.0/24
/ip firewall address-list add list=microsoft address=157.60.31.0/24
/ip firewall address-list add list=microsoft address=167.220.240.0/22
/ip firewall address-list add list=microsoft address=168.61.0.0/16
/ip firewall address-list add list=microsoft address=168.62.0.0/15
/ip firewall address-list add list=microsoft address=191.232.0.0/13
/ip firewall address-list add list=microsoft address=192.48.225.0/24
/ip firewall address-list add list=microsoft address=192.84.159.0/24
/ip firewall address-list add list=microsoft address=192.84.160.0/23
/ip firewall address-list add list=microsoft address=192.197.157.0/24
/ip firewall address-list add list=microsoft address=193.149.64.0/19
/ip firewall address-list add list=microsoft address=193.221.113.0/24
/ip firewall address-list add list=microsoft address=198.49.8.0/24
/ip firewall address-list add list=microsoft address=198.200.130.0/24
/ip firewall address-list add list=microsoft address=198.206.164.0/24
/ip firewall address-list add list=microsoft address=199.30.16.0/20
/ip firewall address-list add list=microsoft address=199.60.28.0/24
/ip firewall address-list add list=microsoft address=199.74.210.0/24
/ip firewall address-list add list=microsoft address=199.103.90.0/23
/ip firewall address-list add list=microsoft address=199.103.122.0/24
/ip firewall address-list add list=microsoft address=199.242.48.0/21
/ip firewall address-list add list=microsoft address=202.89.224.0/21
/ip firewall address-list add list=microsoft address=204.79.135.0/24
/ip firewall address-list add list=microsoft address=204.79.179.0/24
/ip firewall address-list add list=microsoft address=204.79.195.0/24
/ip firewall address-list add list=microsoft address=204.79.252.0/24
/ip firewall address-list add list=microsoft address=204.95.96.0/20
/ip firewall address-list add list=microsoft address=204.152.140.0/23
/ip firewall address-list add list=microsoft address=206.138.168.0/21
/ip firewall address-list add list=microsoft address=206.191.224.0/19
/ip firewall address-list add list=microsoft address=207.46.0.0/19
/ip firewall address-list add list=microsoft address=207.46.33.0/24
/ip firewall address-list add list=microsoft address=207.46.34.0/23
/ip firewall address-list add list=microsoft address=207.46.36.0/22
/ip firewall address-list add list=microsoft address=207.46.40.0/21
/ip firewall address-list add list=microsoft address=207.46.48.0/20
/ip firewall address-list add list=microsoft address=207.46.98.0/24
/ip firewall address-list add list=microsoft address=207.46.64.0/18
/ip firewall address-list add list=microsoft address=207.46.128.0/17
/ip firewall address-list add list=microsoft address=207.68.128.0/18
/ip firewall address-list add list=microsoft address=207.82.250.0/23
/ip firewall address-list add list=microsoft address=208.68.136.0/21
/ip firewall address-list add list=microsoft address=208.76.45.0/24
/ip firewall address-list add list=microsoft address=208.76.46.0/24
/ip firewall address-list add list=microsoft address=208.84.0.0/24
/ip firewall address-list add list=microsoft address=208.84.1.0/24
/ip firewall address-list add list=microsoft address=208.84.2.0/24
/ip firewall address-list add list=microsoft address=208.84.3.0/24
/ip firewall address-list add list=microsoft address=209.1.112.0/23
/ip firewall address-list add list=microsoft address=209.185.128.0/22
/ip firewall address-list add list=microsoft address=209.185.240.0/22
/ip firewall address-list add list=microsoft address=209.240.192.0/19
/ip firewall address-list add list=microsoft address=213.199.128.0/18
/ip firewall address-list add list=microsoft address=216.32.180.0/22
/ip firewall address-list add list=microsoft address=216.32.240.0/22
/ip firewall address-list add list=microsoft address=216.33.240.0/22
/ip firewall address-list add list=microsoft address=64.41.193.0/24
/ip firewall address-list add list=microsoft address=65.55.112.0/24
/ip firewall address-list add list=microsoft address=65.55.171.0/24
/ip firewall address-list add list=microsoft address=65.221.5.0/24
/ip firewall address-list add list=microsoft address=204.176.46.0/24
/ip firewall address-list add list=microsoft address=209.1.15.0/24
/ip firewall address-list add list=microsoft address=216.32.180.0/24
/ip firewall address-list add list=microsoft address=216.34.51.0/24
/ip firewall address-list add list=microsoft address=131.253.16.0/23
/ip firewall address-list add list=microsoft address=131.253.22.0/23
/ip firewall address-list add list=microsoft address=157.58.2.0/23
/ip firewall address-list add list=microsoft address=194.69.104.0/23
/ip firewall address-list add list=microsoft address=191.234.96.0/23
/ip firewall address-list add list=microsoft address=191.234.98.0/23
/ip firewall address-list add list=microsoft address=40.72.0.0/17
/ip firewall address-list add list=microsoft address=40.72.0.0/16
/ip firewall address-list add list=microsoft address=40.72.128.0/17
/ip firewall address-list add list=microsoft address=40.125.128.0/17
/ip firewall address-list add list=microsoft address=40.126.64.0/18
/ip firewall address-list add list=microsoft address=42.159.0.0/18
/ip firewall address-list add list=microsoft address=42.159.64.0/18
/ip firewall address-list add list=microsoft address=42.159.128.0/18
/ip firewall address-list add list=microsoft address=42.159.0.0/16
/ip firewall address-list add list=microsoft address=42.159.192.0/18
/ip firewall address-list add list=microsoft address=103.9.8.0/23
/ip firewall address-list add list=microsoft address=103.9.8.0/22
/ip firewall address-list add list=microsoft address=139.217.0.0/17
/ip firewall address-list add list=microsoft address=139.217.0.0/16
/ip firewall address-list add list=microsoft address=139.217.128.0/17
/ip firewall address-list add list=microsoft address=139.219.0.0/17
/ip firewall address-list add list=microsoft address=139.219.0.0/16
/ip firewall address-list add list=microsoft address=139.219.128.0/17
/ip firewall address-list add list=microsoft address=167.220.244.0/22
/ip firewall address-list add list=microsoft address=192.92.214.0/24
/ip firewall address-list add list=microsoft address=64.4.0.0/18
You probably would want to allow Skype to communicate, so here is short exclude list that allows basic Skype connectivity (no file transfer, etc). You can inspect traffic in your network further and broaden the list in order to allow full Skype functionality, just add whole respective IP clusters instead of only one destionation address that Skype is trying to reach.
/ip firewall address-list add list=skype address=40.64.0.0/10
/ip firewall address-list add list=skype address=23.96.0.0/14
/ip firewall address-list add list=skype address=64.4.0.0/18
/ip firewall address-list add list=skype address=65.52.0.0/14
/ip firewall address-list add list=skype address=157.55.0.0/16
Che