If you do not like that your ISP or government spy on your DNS request, you could use DNS over HTTPS.
https://en.wikipedia.org/wiki/DNS_over_HTTPS
It seems to be in beta (experimental protocol), but it would be nice if MikroTik looks at this.
Here is an video demonstrating an implementation of this:
https://www.youtube.com/watch?v=-jspv9FwgjA
It uses a Linux server as a DNS->HTTPS server.
So in this case I could redirect all UDP port 53 to a server and make this to work.
But getting this inn to the RouterOS would be nice, no extra boxes and a big lift in privacy