Unless I am missing something you can not use SMTP authentication or alternate port numbers to send to mail servers. We enforce SMTP authentication to prevent spammers from using our mail servers without an account, even though we have relay disabled. The reason is most spyware doesnt utilize SMTP authentication, YET and so it is stopped. Also using an alternate port would allow special servers to hide on those ports for sending email. Now I could just make the from address something else, however our mail server does a reverse look up to verify the sender is a legit account and if it is a local account it isnt allowed without SMTP auth. The other issue if I make it originate from say a hotmail account it would then ask hotmail's DNS if the SPF allowed hotmail emails to come from that IP, which it most certainly would not and then be blocked.
If I allow a bypass for the Mikrotiks IP then every NAT customer behind it could then freely send email through our servers, meaning their spyware would then freeflow the outbound stuff.