You probably mean the same, but I wouldn't use "direction", because to me it's confusing term, all dstnat rules are for "input" or incoming packets to router (with one very special exception). But yes, dstnat rules need to be limited. E.g. if there's:
/ip firewall nat
add chain=dstnat protocol=udp dst-port=53 action=redirect
It will catch DNS requests coming from everywhere. It should be something like:
/ip firewall nat
add chain=dstnat protocol=udp dst-port=53 in-interface-list=LAN action=redirect