This assumes a flat landscape, don't forget to use absolute altitudes above sea level where the topography is anything other than flat as a pancake!
As a rule of thumb where all client antennae are at a lower altitude than the main transmitter then down tilt by at least half the antenna's vertical beam width, otherwise you're just sending the signal into Space.
I created an Excel spreadsheet a couple of years ago, it calculates the signal footprint given various elevation differences and distances for different antenna types.
I tried to attach the spreadsheet to this post, but I'm getting weird errors, so I've made the spreadsheet available at
http://www.glenkens.uk.net/files/downtilt.xls.