PPTP with MPPE128 encryption can be a good solution. If you need strong encryption, then IPSEC would be better but more complicated.
Your question is not precise enough. So you'll need to watch here and learn yourself :
http://wiki.mikrotik.com/wiki/Manual:Interface/PPTP
PPTP can be used to bridge at level 2 as well using BCP protocol, if you need Ethernet connectivity between sites.
See here :
http://wiki.mikrotik.com/wiki/Manual:BC ... ridging%29
If you are a beginner, i advice you to ask a Mikrotik Certified professional to do this to avoid security holes.