Unfortunately you decided to blank out essentially all the relevant information in that screen shot.
So you say the source IP, protocol, and port are known, as is the destination IP. Assuming the source IP is 1.1.1.1, the source protocol is TCP, the source port is 1 and the destination IP is 1.1.1.2, simply write a firewall filter rule the specifies the known parts and has an action of drop. Also assuming that the packet is going through the router rather than to the router (the destination IP is not an IP address assigned to a router interface after destination NAT) you would use the forward chain, otherwise use the input chain:
/ip firewall filter
add chain=forward src-address=1.1.1.1 protocol=tcp src-port=1 dst-address=1.1.1.2 action=drop
All of this is explained in the manual:
http://wiki.mikrotik.com/wiki/Manual:IP/Firewall/Filter
http://wiki.mikrotik.com/wiki/Manual:Packet_Flow